Fasting, Neurogenesis, and Brain Health

created on 5/21/23 @ 03:51PM, updated on 5/21/23 @ 07:26PM

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wsf246
William Fan

There are many studies that show the role of fasting and neurogenesis, specifically time delayed restricted eating versus pure calorie restriction. All of the studies I've seen so far are in mice.

However, the original question is whether neurogenesis leads to behavioral change. Neurogenesis for adults appears to largely happen in the hippocampus which is understood to be the center for learning and memories. This review examines other potential ways the hippocampus, and thus the neurogenesis caused by fasting, impacts behaviors.

Although it is uncertain how hippocampal roles in learning/memory and emotion are related, it is clear that an accurate picture of the function of new neurons in the hippocampus must account for all of their behavioral effects, including those with emotional but not mnemonic components. One potential role for the new neurons, and the rest of the hippocampus, that appears to fit with both emotional and memory-related findings is in predicting possible outcomes of novel or ambiguous events and in emotionally biasing these predictions.

Here they show in a few studies that mice with lesioned hippocampuses change their behavior when faced with new challenges like potential predators they hadn't interacted with before. This review hypothesizes that the hippocampus will bias future behaviors in new situations through emotional learnings.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612417/

wsf246
William Fan

This study in mice tests dietary restriction (DR) vs ad libitum (AL) diets mice maintained for 3 months. This study specifically tests whether ghrelin, the "hunger hormone", is a key contributor to the impacts of neurogenesis and dietary restriction. They did so by testing ghrelin knockout (GKO) mice and wild-type (WT) mice on DR and AL diets.

These results suggest that elevated levels of ghrelin during DR may have an important role in the enhancement of neurogenesis induced by DR.

https://pubmed.ncbi.nlm.nih.gov/25735661/

Ghrelin is required for dietary restriction-induced enhancement of hippocampal neurogenesis: lessons from ghrelin knockout mice - PubMed

Ghrelin is required for dietary restriction-induced enhancement of hippocampal neurogenesis: lessons from ghrelin knockout mice - PubMed

wsf246
William Fan
wsf246
William Fan

This study addressed whether the beneficial effects of intermittent fasting (IF) on cognition are due to a decrease in total amount of calories consumed or to the increased interval between meals. IF takes the form of every other day feeding matched against 10% daily calorie restriction (CR) intake. The experiment is conducted in mice.

IF has previously been demonstrated to enhance learning and consolidation processes and to partly reverse age-associated impairment in motor coordination and memory function in rodents. Similarly, 30–40% CR has been shown to improve learning and memory performance.

  • After 3 months under IF, female C57BL6 mice exhibited improved long-term memory retention

IF, but not CR, however, improved cognitive performance without reducing levels of Alzheimer’s pathology, suggesting that IF promotes resilience to pathology and neuronal injury

  • These data suggest that IF is superior to 10% CR in enhancing memory and identifies Klotho (Kl) as a novel candidate molecule that regulates the effects of IF on cognition likely via adult hippocampal neurogenesis (AHN) enhancement

Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho - Molecular Psychiatry

Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho - Molecular Psychiatry

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